Latvian Biomedical Research and Study Centre

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18
MAR
2022

From the world of insects to the finished vaccine

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18
MAR
2022

The use of chemical weapons can also cause damage to the aggressor himself

Ķīmisko ieroču pielietošana var radīt zaudējumus arī pašam agresoram | tv3.lv

18
MAR
2022

The omicron type BA.2 dominates in Latvia

Latvijā dominē omikrona paveids BA.2 / 15.03.2022 / Raksts / LTV.LV (lsm.lv)

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Programming of breast cancer microenvironment to create a ”hot” immune-responsiveness in cancer
Investigate biotic stress induced inter-plant molecular signals and responses in mycorrhizal fungi-connected plants
Research of microbiota-derived extracellular vesicle role on breast cancer by using gut-breast cancer axis on a chip
Molecular design of DNA phage-derived endolysins for targeting Gram-negative bacteria
HBc VLP-based platform for the development of a recombinant vaccine prototype against SARS-Cov-2
Structural and functional characterization of the paralogous gene family PFam12 member proteins from the Lyme disease causing agent Borrelia burgdorferi to determine their role in the pathogenesis of Lyme disease
Development of carbonic anhydrase IX test biosensor for cancer screening
Gut microbiota composition in relation to extrinsic factors and health status in infants and toddlers: prospective analysis of faecal microbiota composition by meategenomic sequencing in children up to 36 months of age
Strengthening LU doctoral capacity under the new doctoral model
Identification of molecular determinants associated with the risk for various COVID-19 long term effects: a comprehensive cohort-based study in Latvian population
The development of an efficient pilot-scale leghemoglobine production technology, based on recombinant Pichia pastoris and Kluyveromyceslactis fed-batch fermentations (BioHeme)
Large area deposition technologies of multifunctional antibacterial and antiviral nanocoatings
Enclosed lung on a chip system development suitable for respiratory disease research in BSL3 and microgravity systems (LoCBox)
AI-improved organ on chip cultivation for personalised medicine (AImOOC)
Exploring the molecular mechanisms behind the effects of physical exercise on breast cancer prevention (CancerBeat)
Development of a novel microfluidic device for label-free quantification of prostate cancer-derived extracellular vesicles and analysis of their RNA content (PROCEX)
DECIDE - Development of a dynamic informed consent system for biobank and citizen science data management, quality control and integration
Usage of conservative borrelia protein as vaccine target
An integrated population based Latvian genome reference and its applicability to personal risk estimation for metabolic traits
Testing of patient-derived stem cell extracellular vesicles loaded with drugs in a personalized lung-cancer on-chip platform (LoC4Ev)
Tuberculosis treatment: exploring the perspectives for personalised therapy
Dissecting the associations between glucose variability, intestinal derangements and progression of diabetic nephropathy in type 1 diabetes
Characterization and dynamics of seed-associated microbiome in weed soil seed-bank
Low-coverage whole-genome sequencing analysis of polygenic mechanisms of high cholesterol levels in patients with clinically diagnosed or possible familial hypercholesterolemia
GUT-BLOOD-LIVER AXIS: CIRCULATING MICROBIOME AS NON-INVASIVE BIOMARKER FOR INFLAMMATORY BOWEL DISEASE (IBD) AND PRIMARY SCLEROSING CHOLANGITIS (PSC) [BLOOD-BIOME]
Whole genome sequencing of tuberculosis for routine clinical use in Latvia: evidence-based design and concept evaluation
Evolutionary adaptation of non-conventional industrial yeasts Kluyveromyces marxianus to acetic acid stress and evaluation of adaptation mechanisms
Bacteriophage–derived dsRNA as a potential agent against coronovirus
Genetic investigation of urban Northern goshawks (Accipiter gentilis) in Riga - launching into wild population genomics
Characterization of DNA bacteriophages isolated from the insect intestine microflora
Deciphering the genetic mechanisms of the individuals with isolated cleft palate by whole genome sequencing
Pathogenicity of human Hepatitis C virus relying on enzymatic properties of viral RNA-dependent RNA-polymerase
Structural and immunological characterization of potential Lyme disease vaccine candidates
Research of extracellular vesicle content from gut microbiome and its’ role in cancer development by applying gut on chip system
Challenging African Swine Fever outbreaks with innovative VLP-based vaccines” (ASF-INNOVAC)
European resercher Night in Latvia 2020
Towards new therapeutic and prophylactic treatments against Covid-19 and coronaviruses
Establishment of COVID-19 related biobank and integrated platform for research data in Latvia
Integration of reliable technologies for protection against Covid-19 in healthcare and high-risk areas
Multidisciplinary approach to monitor, mitigate and contain COVID 19 and other future epidemics in Latvia
Clinical, Biochemical, immunogenetic paradigms of Covid-19 infection and their correlation with sociodemographic, etiological, pathogenetic, diagnostic, therapeutically and prognostically important factors to be included in guidelines
New Technologies for Targeted Tracing, Testing and Treatment of COVID-19 Patients (3-T project)
Clinical, Biochemical, immunogenetic paradigms of Covid-19 infection and their correlation with sociodemographic, etiological, pathogenetic, diagnostic, therapeutically and prognostically important factors to be included in guidelines
Clinical, Biochemical, immunogenetic paradigms of Covid-19 infection and their correlation with sociodemographic, etiological, pathogenetic, diagnostic, therapeutically and prognostically important factors to be included in guidelines.
Strengthening GPCR functional research through improvement of novel peptidic ligand identification system
Beyond 1M Genomes
Effect of the Nordic diet on composition and functional profile of faecal microbiota and symptoms of fatigue in patients with mild and moderate ulcerative colitis
Interaction and dynamics of intestinal IgA and gut microbiome profile during antidiabetic therapy
Oligomer – Focused Screening and Individualized Therapeutics to target Neurodegenerative Disoders” (OligoFIT)
Development of anti-myostatin vaccine for promotion of livestock animal muscle growth
Dynamic human microbiome data platform and interpretation tool for personalized health recommendations
Structural and functional studies of Ryegrass mottle virus-encoded proteins
Association of human intestinal and blood microbiome composition with general state of health and mortality within population of Latvia
Structural and kinetic studies of human carbonic anhydrases as multiple drug targets
The role of “mitotic slippage” in the origin of amoeboid metastatic cell in therapy resistant cancers
Investigation of the origin and dynamics of human blood microbiome, and its role in chronic disease
Development of plant virus-based bacterial vaccine production platforms
Microfluidic field flow fractionation for high throughput extra-cellular vesicle separation
Multidisciplinary study of community-acquired sepsis survivors in Latvia
Characterization of general and mastitis susceptibility genetic background for Latvia’s (indigenous) local breeds of ruminants
Nanoparticle Transfer Through Endothelial Barrier (NanoTENDO)
Integration of knowledge and biobank resources in comprehensive translational approach for personalized prevention and treatment of metabolic disorders (INTEGROMED)
Establishing an algorithm for the early diagnosis and follow-up of patients with pancreatic neuroendocrine tumors (NExT)
Clinical utility of extracellular vesicle-enclosed human and microbial transcriptomes
RNA molecular determinants in development of pituitary adenoma
Role of miRNAs in the host-gut microbiome communication during metformin treatment in the context of metabolic disorders
The determination of rare inherited diseases' causative mechanisms using whole genome sequencing approach
Functional and genetic research of rare unidentitied neuromuscular disorders
Understanding the biology of the minimal residual disease after targeted therapy of BRAF mutant melanoma
Studies on Ribes plants, Cecidophyopsis mites and Blackcurrant Reversion virus for sustainable resistance breeding and cultivation of Ribes
Identification of clinical subgroups of Type 2 diabetes mellitus and application of pharmacogenetics in development of personalized antidiabetic therapy
Combination of system and molecular biology approaches for discovery and characterization of plant enzymes for industrial processes
Optimization of novel plant derived enzyme expression in microorganisms for biotechnological application
Mathematical model of pharmacokinetics for personalized optimization of metformin therapy
Interplay of Environmental and Genetic Factors in the Immunologic Mechanisms of Thyroid Autoimmune Diseases
Ethically and socially responsible governance of research biobanks in Latvia: analysis of opinions of public, donors and researchers
Role of natural killer cells in the therapeutic efficacy of oncolytic measles virus
Investigation of the chemokine receptors CCR1 and CCR2 and EBV infection aimed on disclosure of new markers that can predict the high risk for progression of chronic lymphocytic leukemia
Gender, sex and status in Iron Age Latvia (7th – 12th centuries AD)
Prostate cancer-derived extracellular vesicles as liquid biopsies and therapeutic targets
Functional programming of tumor-associated macrophages with viral immunotherapy vectors in breast cancer model
The characterization and analysis of mitochondrial DNA mutations and variants of unknown significance using transmitochondrial cytoplasmic hybrid cell models.
Support for the integration of the Latvian Biomedical Research and Study Centre into the European Research Area and Infrastructure objects
Investigation of interaction of smoked dietary products with gut microbiome
Exploitation of extracellular vesicles for precision diagnostics of prostate cancer
Infrastructure of the Latvian Biomedical Research and Study Center for the strengthening of research and technology transfer capacities in the fields of biomedicine and biotechnology
Engineering of extracellular vesicles to transfer tumor suppressor miRNA to cancer cells
Structural and functional studies of Lyme disease agent Borrelia burgdorferi outer surface proteins to reveal the mechanisms of pathogenesis with the intention to create a new vaccine
sRNAflow – a tool for analysis of small RNA-seq data
Precision medicine test for the therapeutic decisions and monitoring of treatment response in breast cancer
Development of new antimicrobial agents targeting Gram-positive bacterial sortase A
Obtaining and characterization of virus-like particles of novel RNA phages
Diagnostic and immunoprotective potential of influenza virus hemagglutinin stalk peptide: generation of novel vaccine prototypes
Long term effects of H.pylori eradication on Gastro intestinal tract microbiome and development of screening system for detection of extended-spectrum beta-lactamase coding genes within feces samples
The impact of burial environmental microbiome on biomolecular archeology and the ancient tuberculosis research
Molecular design of new luminescent compounds for diagnostic purposes
Assessment of magnitude and importance of vectorborne Babesiosis in Latvia: epidemiological and diagnostic approach
Molecular markers of pituitary tumor development, progression and therapy response
Investigation of interplay between multiple determinants influencing response to metformin: search for reliable predictors for efficacy of type 2 diabetes therapy
Development of orphan G-protein coupled receptor peptidic ligand identification system
Function Determining Chromatin Self-Organization after Heregulin Stimulation of Gene Activities and Cancer Cell Differentiation
Structural studies of a Borrelia burgdorferi bacteriophage
Development of a bacterial microcompartment-based nanoreactor platform for metal-containing nanoparticle synthesis
Evaluation the potential of virus-like particles carrying carbonic anhydrase IX as anti-cancer vaccine
Development and introduction of innovative methods in clinical practice for the diagnosis and treatment of malignant tumours using molecularly targeted radionuclides produced in Latvia

News

From the world of insects to the finished vaccine

The use of chemical weapons can also cause damage to the aggressor himself

The omicron type BA.2 dominates in Latvia

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