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Development of a novel microfluidic device for label-free quantification of prostate cancer-derived extracellular vesicles and analysis of their RNA content (PROCEX)

Project Title: „Development of a novel microfluidic device for label-free quantification of prostate cancer-derived extracellular vesicles and analysis of their RNA content (PROCEX)”

Funding: European Regional Development Fund (ERDF), Measure 1.1.1.1 “Support for applied research”

Project No.: 1.1.1.1/20/A/045

Period: 1 May 2021 – 30 November 2023

Project costs: 540 540.54 EUR

Principle Investigator: Dr. biol. Aija Linē

Cooperation partner: SIA “Cellboxlab” 

 

Project summary:

This project aims at developing a radically new technology for non-invasive detection and monitoring of prostate cancer (PC) based on label-free quantification of PC-derived extracellular vesicles (EVs) and analysis of their RNA content. This technology will combine a multi-stage microfluidic system with optical resonators and novel reagents – nanobodies allowing to capture, quantify and analyse the RNA cargo of specific PC-derived EV subpopulations in the blood or urine. The main outcome of the project will be a prototype of the PROCEX device. Its performance will be tested with the clinical samples from well-annotated cohort of PC patients and controls. We expect that this project will lead to the development of novel point-of-care device that has the potential to improve the diagnostics and treatment outcomes in cancer patients. Currently, this technology is at TRL2 and we expect that at the end of the project it will reach TRL4.

 Information published 05.05.2021.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".