Research Projects All Projects
Projects

Quick links

Development of cancer-specific autoantibody assay for early detection of gastric cancer

 

 Title of the project: “Development of cancer-specific autoantibody assay for early detection of gastric cancer”

This project is supported by the European Regional Development Fund, project No. 2013/0052/2DP/2.1.1.1.0/13/APIA/VIAA/019

Collaboration partners: Latvian Biomedical Research and Study centre, GASTRO Ltd, AHL Ltd.

Funding: 374 746.02 EUR (BMC – 159 361,64 EUR, GASTRO Ltd – 106 715,39 EUR, AHL Ltd – 94 265,26 EUR)

Project duration: 20 months (1. January, 2014 – 31. August, 2015)

Project leader: Dr. Aija Linē

 

The main aim of the project is to develop a novel in vitro diagnostic tool – an autoantibody-based assay for the early detection of gastric cancer (GC). The specific aims of the project are the following:

To define a panel of antigens with GC-specific reactivity using a previously established cancer antigen database and clone collection, and  to establish its diagnostic value in a retrospective study.

To establish its relevance for discriminating GC from other cancers of digestive system.

To develop a database of the retrospectively and prospectively collected clinical samples of GC patients and population-based cohort.

To validate the diagnostic performance of the autoantibody-based assay in a population-based cohort.

To evaluate the suitability of PYV virus-like particles as epitope carriers for the production of the autoantibody assay.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".