Immunomodulating properties of bacteriophage derived dsRNA of different size and their use as vaccine adjuvants
Project title: Immunomodulating properties of bacteriophage derived dsRNA of different size and their use as vaccine adjuvants
Funding: Taiwan-Latvian-Lithuanian collaboration project
Project partners: National Cancer Institute, Center of Scientific Resesarch (NCI), Lithuania; Institute of Biomedical Sciences, Academia Sinica (IBMS, AS), Taiwan
Principle Investigator: Dr.biol. Dace Pjanova
Double-stranded ribonucleic acid (dsRNA), regardless of its origin and nucleotide sequence, exhibit multiple biological activities including the establishment of an antiviral state and the modulation of immune response, which makes them promising not only for antiviral therapy but also in adjuvant setting for vaccines against viral infection and cancer. It has been shown that biological activity of dsRNA is largely dependent on its molecule size. Here we propose to investigate the biological activity of dsRNA molecules of different size obtained from bacteriophage-infected E.coli cells with the aim to select the most effective molecules for both antiviral therapy and vaccine adjuvants.