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Investigation of interaction of smoked dietary products with gut microbiome

 

Funding: European Regional Development Fund (ERDF) “On Implementation of Activity 1.1.1.2 “Post-doctoral Research Aid” of the Specific Aid Objective 1.1.1 “To increase the research and innovative capacity of scientific institutions of Latvia and the ability to attract external financing, investing in human resources and infrastructure” of the Operational Programme “Growth and Employment”

Project Title:Investigation of interaction of smoked dietary products with gut microbiome

Project Nr.: 1.1.1.2/VIAA/1/16/128

Period: 36 month (1st January 2018 – 31 st December 2020)

Project costs: 133 806,00 EUR

Project implementer: Dr.biol. I. Kalniņa

Considering the immense choice of harboured enzymes the gut microbiome is a serious contributor to biotransformation of incoming compounds with a prominent role in health and disease. Wood smoke used in processing of food products for flavouring and preservation contains a great variety of compounds with potential to interact with the microbiome. The main objective of the project will be multidimensional investigation of the impact smoked food especially fish consumption exerts on human gut microbiome to gain insight in the responding functional pathways and metabolic consequences. The study will be designed as the crossover dietary intervention including following experimental steps: evaluation of taxonomic and functional composition of the microbiome in humans, detailed characterisation of distinct target communities using gnotobiotic mice, investigation of impact of smoke compounds on microbial communities residing in distinct sections of the gut. Implementation of the proposed project will give insight in the mutual interaction of bacterial taxa and the role individual members play in the community, as well as add mechanistic understanding on "microbiome to host" metabolic crosstalk. Answering these questions will contribute to the data pool necessary for designing microbiome based tools and consultation on dietary choice to improve healthcare.

Information published 02.01.2018.

 

Progress of the project

1 January 2018 - 31 March 2018

 The project is aimed at investigation of the impact of smoked food consumption on the human gut microbiome. It is expected that the crossover dietary intervention study will provide novel information not only on the response of gut microbiome to the smoked foods, but also wide spectrum of other food items commonly included in daily diet. During the first quarter of the project implementation study specific informed consent forms and questionnaires for diet and lifestyle related information collection have been elaborated. The project protocol has been submitted for consideration to the Central Medical Ethics Committee. Currently planning of the dietary intervention stage and survey of potential participants is in progress.

Information published 29.03.2018.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".