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Plant virus-derived vaccine technology platform

Project Title: „Plant virus-derived vaccine technology platform”

Funding: European Regional Development Fund (ERDF), Measure 1.2.1. Specific support goal "To Increase the Private Sector Investments R&D"; measure 1.2.1.2. "Support for Improvement of Technology Transfer System" “Industry‑Driven Research”

Project Nr.: KC-PI-2017/83 

Technical and economic feasibility study and the development of commercialisation strategy that will be accomplished within the first 6 months (30 th January 2017 – 29 th July 2018)

Technical and economic feasibility study and the development of commercialisation strategy costs: 27 777,77 EUR

Principle Investigator: Dr. biol. A.Zeltiņš

 

 

The aim of the project is the development of vaccine platform, based on plant virus-like particles (VLPs). These platform VLPs will serve as a core component of various prophylactic and therapeutic vaccines.

To create a new plant VLP vaccine platform for a variety of vaccines, first, the plant VLPs containing strong T-cell epitopes potentially stimulating T-cell activity will be found using databases available in Internet (eg., www.iedb.org). The VLP candidates for platform development will be selected from plant VLPs, which are constructed during previous projects. If necessary, new plant VLP candidates will be obtained using gene synthesis, expression in recombinant micro-organisms and subsequent purification. Plant VLPs will be characterized by physical and chemical methods, as well as in mouse immunization experiments. Furthermore, most promising plant VLP will be tested in experiments with donor blood cells to select plant VLPs, which are capable of stimulating human immune cells. VLPs with the most suitable properties will serve as a platform for the creation of a variety of vaccines.

 

During the 1st phase of the project, a technical and economic feasibility study and commercialisation strategy will be developed.

 

Information published 30.01.2018.



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".