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Total synthesis of analogues of natural compounds and investigation of anti-cancer activity

Title of the project: “Total synthesis of analogues of natural compounds and investigation of anti-cancer activity”

The project is being carried out within 1.1.1.2 activity of European Social Fund (ESF) “Attraction of human resources to science”

Project ID: 2013/0026/1DP/1.1.1.2.0/13/APIA/VIAA/006

Project length: 19 months (November 1st 2013- May 18th 2015)

Financing available to BMC: 20 260,74 EUR

Leading partner: Latvian Institute of Organic Synthesis

 

 The aim of the project is to synthetize and improve diazonamides – macrocyclic peptides from ascidian Diazona angulata with high anti-cancer activity.

The leading parnner of the project is Institute of Organic Synthesis. BMC is collaborating parner and carries out following activities:

1)      Establishing the crystallization conditions of diazonamide A in complex with its target enzyme – modiefied ornithine deltaaminotransfrease (MOAT)

2)      Collecting high resolution x-ray diffraction data from the obtained crystals



Mājas lapas izstrādi finansēja ERAF 2.1.1.2. aktivitātes projekts Nr. 2010/0196/2DP/2.1.1.2.0/10/APIA/VIAA/004 "Latvijas biomedicīnas pētījumu integrācija Eiropas zinātnes telpā".