Slimību patoģenēzes ģenētisko un molekulāro mehānismu izpēte un jaunu terapijas un diagnostikas līdzekļu izstrāde

Projekta gaitā tapušās publikācijas

1. Ranka R., Petrovskis I., Sominskaya I., Bogans J., Bruvere R., Akopjana I., Ose V., Timofejeva I., Brangulis K., Pumpens P., Baumanis V. Fibronectin-binding nanoparticles for intracellular targeting addressed by B. burgdorferi BBK32 protein fragments. Nanomedicine. (2013) 9:65-73.

2. Freivalds J., Dislers A., Ose V., Pumpens P., Tars K., Kazaks A. Highly efficient production of phosphorylated hepatitis B core particles in yeast Pichia pastoris. Protein Expr Purif. (2011) 75:218-24

3. Kazaks A., Voronkova T., Rumnieks J., Dishlers A., Tars K. Genome Structure of Caulobacter Phage phiCb5. J Virol. (2011) 85: 4628-31. (Raksts ieskaitīts kā 0.5 raksti, jo publikācijas tapšanā bija iesaistīts arī ERAF projekts)

4. Rumnieks J., Tars K. Crystal structure of the read-through domain from bacteriophage Qβ A1 protein. Protein sci (2011) 20:1707-12

5. Tars K., Rumnieks J., Zeltins A., Kazaks A., Kotelovica S., Leonciks A., Sharipo J., Viksna A., Kuka J., Liepinsh E., Dambrova M. Crystal structure of human gamma-butyrobetaine hydroxylase. Biochem Biophys Res Commun. (2010) 398:634-9.

6. Plevka P., Kazaks A., Voronkova T., Kotelovica S., Dishlers A., Liljas L., Tars K. The structure of bacteriophage phiCb5 reveals a role of the RNA genome and metal ions in particle stability and assembly. J Mol Biol. (2009) 391:635-47

7. Bakteriofāga Qβ caurlasīšanas proteīna 2 struktūras ar pieejas kodiem 3RLC un 3RLK, bakteriofāga phiCb5 2 struktūras ar pieejas kodiem 2W4Z un 2W4Y

8. Kalnina I., Geldnere K., Tarasova L., Nikitina-Zake L., Peculis R., Fridmanis D., Pirags V., Klovins J. Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population. Exp Clin Endocrinol Diabetes. (2012) 120(8):466-8.

9. Ignatovica V., Megnis K., Lapins M., Schiöth H.B., Klovins J. Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system. FEBS J. (2012) 279(1):180-91.

10. Ignatovica V., Latkovskis G., Peculis R., Megnis K., Schioth H.B., Vaivade I., Fridmanis D., Pirags V., Ergis A., Klovins J. Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population. Mol Biol Rep. (2012) 39(2):1917-25.

11.  Mihailova A., Mikazane H., Klovins J., Nikitina-Zake L. Association of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and Kruppel-like factor 12 (KLF12) rs1324913 single nucleotide polymorphisms with rheumatoid arthritis in Latvian population. Scand. J. Rheum (2011) 40: 491-2

12. Ciganoka D., Balcere I., Kapa I., Peculis R., Valtere A., Nikitina-Zake L., Lase I., Schiöth H.B., Pirags V., Klovins J. Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly. Eur J Endocrinol (2011)165(4):517-25

13. Peculis R., Latkovskis G., Tarasova L., Pirags V., Erglis A., Klovins J. A non-synonymous variant I248L of the adenosine A3 receptor is associated with coronary heart disease in a Latvian population, DNA and Cell Biology, (2011) 30(11):907-11.

14. Ignatovica V., Petrovska R., Fridmanis D., Klovins J. Expression of human melanocortin 4 receptor in Saccharomyces cerevisiae. Cent Eur J Biol. (2011) 6(2):167-175.

15. Pliss L., Brakmanis A., Ranka R., Elferts D., Krumina A., Baumanis V. The link between mitochondrial DNA hypervariable segment I heteroplasmy and ageing among genetically unrelated Latvians. Exp Gerontol. (2011) ;46(7):560-8.

16. Ducena K., Abols A., Vilmanis J., Narbuts Z., Tars J., Andrejeva D., Line A., Pirags V. Validity of multiplex biomarker model of 6 genes for the differential diagnosis of thyroid nodules.Thyroid Res. (2011) 4:11.

17. Erenpreisa J., Cragg MS., Anisimov AP., Illidge TM. Tumor cell embryonality and the ploidy number 32n: Is it a developmental checkpoint? Cell Cycle. (2011) 10:1873-4.

18.  Erenpreisa J., Salmina K., Huna A., Kosmacek E.A., Cragg M., Ianzini F., Anisimov A.Polyploid tumour cells elicit para-diploid progeny through de-polyploidising divisions and regulated autophagic degradation. Cell Biol Int. (2011) 35:687-95.

19. Huna A., Salmina K., Jascenko E., Duburs G., Inashkina I., Erenpreisa J. Self-renewal signalling in pre-senescent tetraploid IMR90 cells - J Aging Research (2011) 2011: 103253.

20. Salmina K., Jankevics E., Huna A., Perminov D., Radovica I., Klymenko T., Ivanov A., Jascenko E., Scherthan H., Cragg M., Erenpreisa J. Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells. Experimental Cell Research (2010) 316:2099-2112.

21. Erenpreisa J. and Cragg M . MOS, aneuploidy and the ploidy cycle of cancer cells. Mini-review/comment. Oncogene (2010) 29:5447-51.