Par mums

Olita Heisele , Dr. biol.

Vadošā pētniece
Telefons: +371 67808215
E-pasts: olita@biomed.lu.lv

Projekti

• Prognostiska imūnterapijas lietderīguma un efektivitātes testēšana: metodes izveide personalizētai imūnterapeitisko preparātu pielietošanai onkoloģijā
• MCIR gēna variantu loma melanomas attīstībā pacientiem ar un bez izmaiņā CDKN2A un CDK4 gēnos
• Ģenētiski determinētie un fenotipiskie riska faktori un iedzimtās melanomas attīstībā
• Melanomas ģenētiskie un vides riska faktori; izpausme uzvedības maiņā.
• Apoptisko procesu inducēšana melanomas šūnās kā viens no imūnterapijas nosacījumiem
• Ģenētisko izmaiņu loma iedzimtās melanomas attīstībā un tās agrīnās diagnostikas iespējas

Publikācijas

• Starptautiskas

• Melanoma risk associated with MC1R gene variants in Latvia and the functional analysis of rare variants. A Ozola, Azarjana K, Doniņa S, Proboka G, I Mandrika, R Petrovska, Čēma I, O Heisele, Eņģele L, Štreinerte B, D Pjanova , Cancer Genet. Mar;206(3):81-91. , 2013
• Skin examination behavior: the role of melanoma history, skin type, psychosocial factors, and region of residence in determining clinical and self-conducted skin examination Kasparian NA, Bränström R, Chang YM, Affleck P, Aspinwall LG, Tibben A, Azizi E, Baron-Epel O, Battistuzzi L, Bruno W, Chan M, Cuellar F, Debniak T, D Pjanova, Ertmanski S, Figl A, Gonzalez M, Hayward NK, Hocevar M, Kanetsky PA, Leachman S, Bergman W, O Heisele, Palmer J, Peric B, Puig S, Schadendorf D, Gruis NA, Newton-Bishop J, Brandberg Y; Melanoma Genetics Consortium (GenoMEL) , Arch Dermatol. 148(10):1142-51. , 2012
• Melanoma risk factors, perceived threat and intentional tanning: an international online survey. Bränström R, Chang YM, Kasparian N, Affleck P, Tibben A, Aspinwall LG, Azizi E, Baron-Epel O, Battistuzzi L, Bruno W, Chan M, Cuellar F, Debniak T, D Pjanova, Ertmański S, Figl A, Gonzalez M, Hayward NK, Hocevar M, Kanetsky PA, Leaf SL, van Nieuwpoort FA, O Heisele, Palmer J, Peric B, Puig S, Ruffin AD, Schadendorf D, Gruis NA, Brandberg Y, Newton-Bishop J. , Eur J Cancer Prev. 19(3):216-26 , 2010
• Predictors of sun protection behaviors and severe sunburn in an international online study. Bränström R, Kasparian NA, Chang YM, Affleck P, Tibben A, Aspinwall LG, Azizi E, Baron-Epel O, Battistuzzi L, Bergman W, Bruno W, Chan M, Cuellar F, Debniak T, D Pjanova, Ertmanski S, Figl A, Gonzalez M, Hayward NK, Hocevar M, Kanetsky PA, Leachman SA, O Heisele, Palmer J, Peric B, Puig S, Schadendorf D, Gruis NA, Newton-Bishop J, Brandberg Y , Cancer Epidemiol Biomarkers Prev. 19(9):2199-210 , 2010
• Identification of a CDK4 R24H mutation-positive melanoma family by analysis of early-onset melanoma patients in Latvia. D Pjanova, Molven A, Akslen LA, Engele L, Streinerte B, Azarjana K, O Heisele , Melanoma Res. 19(2):119-22 , 2009
• CDKN2A and CDK4 variants in Latvian melanoma patients: analysis of a clinic-based population. D Pjanova, Engele L, Randerson-Moor JA, Harland M, Bishop DT, Newton Bishop JA, Taylor C, Debniak T, Lubinski J, Kleina R, O Heisele , Melanoma Res. 17(3):185-91. , 2007
• Clinical value of melanoma associated antigens. O Heisele, Ferdats A, Engele L, Rupais A , J Tumor Marker Oncology 16(2):106 , 2001
• Melanoma Associated Antigens as Additional Markers of Tumor Progression. O Heisele, Ferdats A, Engele L , J Tumor Marker Oncology 15(2):147-53 , 2000

• Vietēja mēroga

• Low-penetrance melanoma risk gene polymorphisms in Latvian population. A Ozola, Baginskis A, Azarjana K, Doniņa S, Proboka G, Čēma I, O Heisele, Eņģele L, Štreinerte B, D Pjanova , Environmental and Experimental Biology, 12: 55–56 , 2014
• Genetic alterations in melanoma development. D Pjanova, Azarjana K, Čēma I, O Heisele , Proc. Latvian Acad. Sci. 63(3): 20-30 , 2009
• Analysis of Latvian melanoma families for 9p21 germline deletions by multiplex ligation-dependent probe amplification approach D Pjanova, O Heisele, Engele L, Randerson-Moor JA, Kukalizch K, Bishop DT, Newton Bishop JA , Acta Universitatis Latviensis 710:7-16. , 2006
• CDKN2A mutations and loss of heterozygosity in primary melanomas D Pjanova, Eņģele L, V Rovīte, O Heisele , Proc. Latvian Acad. Sci. Secion B. 60 (2/3):98:100. , 2006
• Tumour suppressor gene CDKN2A/p16 germline mutations in melanoma patients with additional cancer in their family history D Pjanova, O Heisele, Engele L, Desjatnikova I , Acta Universitatis Latviensis 662:25-32. , 2003
• Iedzimtība un slimības O Heisele, D Pjanova , Doctus 46-48 , 2003
• Echovirus-mediated biotherapy for malignant tumours: 40 years of invesigation. R Brūvere, O Heisele, Ferdats A, Rupais A, Mucenice A , Acta Medica Lituanica 9: 97-100 , 2002
• Phenotypical characteristics of leukocyte membranes in Chernobyl clean-up workers from Latvia: use of the fluerescent probe ABM. Kalnina A, N Gabruševa, R Brūvere, Zvagule T, O Heisele, Volrāte Ā, Feldmane G, Meirovics I , Proc. Latvian Acad. Sci. 55(1): 6-14 , 2001
• Physicall-chemical characteristics of leukocyte membranes in chernobyl clean-up workers from Latvia. Problems of Disaster Medicine and Emergency Medical Acid. Kalnina I, R Brūvere, Zvagule T, N Gabruševa, O Heisele, Volrate A, Feldmane G, Meirovics I , Proc. Acad. Sci. Ukraine pp.517-522 , 2000
• The parameter of immune system of fire-fighters and security persons. Lielpetere I, R Brūvere, O Heisele, Volrate A, Feldmane G , Jums, kolēģi Nr.10 , 2000

• Konferenču tēzes

• The Role of Rare MC1R gene polymorphisms on Receptor Cell Surface Expression and Functions. A Ozola, R Petrovska, I Mandrika, O Heisele, D Pjanova , Annual Paris Melanoma Conference. Paris, France. Abstract book, p.37. , 2012
• Melanokortīna 1. receptora gēna polimorfismu funkcionālās ietekmes izvērtēšana, izmantojot konfokālo lāzerskenējošo mikroskopiju. A Ozola, R Petrovska, I Mandrika, O Heisele, D Pjanova , Daugavpils Universitātes konference “Jaunu fluorescentu materiālu un metožu izstrāde un pielietošana". Abstrakts, p.23. , 2012

Ātrās saites

• BMC e-pasts
• Iepirkumi
• Iepirkumu arhīvs
• Masu medijiem
• EURAXESS