Par mums

Grupas

• J. Kloviņa grupa

Projekti

• Agrīnas diagnostikas un monitoringa algoritma izveide aizkuņģa dziedzera neiroendokrīno audzēju pacientiem (NExT)
• Molekulārie RNS faktori hipofīzes adenomas attīstībā
• Ārvides un ģenētisko faktoru mijiedarbība vairogdziedzera autoimūno slimību imunoloģiskās attīstības mehānismos
• Ētiski un sociāli atbildīga pētniecības biobanku pārvaldība Latvijā: sabiedrības, donoru un zinātnieku viedokļu analīze

Publikācijas

• Starptautiskas

• Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results V Rovīte, Wolff-Sagi Y, L Zaharenko, L Ņikitina-Zaķe, E Grēns, J Kloviņš , J Epidemiol. 2018 Mar 24. doi: 10.2188/jea.JE20170079. [Epub ahead of print] PubMed PMID: 29576601 , 2018
• Functional Characteristics of Multipotent Mesenchymal Stromal Cells from Pituitary Adenomas K Megnis, I Mandrika, R Petrovska, Stukens, J., V Rovīte, Balcere, I., Jansone, L.S., R Pečulis, V Pīrāgs, J Kloviņš , Stem Cells International, 2016, art. no. 7103720 , 2016
• Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas R Pečulis, Balcere, I., V Rovīte, K Megnis, Valtere, A., Stukens, J., Arnicane, L., L Ņikitina-Zaķe, Lejnieks, A., V Pīrāgs, J Kloviņš , European Journal of Endocrinology, 175 (2), pp. 145-153 , 2016
• The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity V Rovīte, R Petrovska, I Vaivade, I Kalniņa, D Fridmanis, L Zaharenko, R Pečulis, V Pīrāgs, Schioth HB, J Kloviņš , Mol Biol Rep. 41(3):1491-500 , 2014
• Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia. V Rovīte, Maurins U, K Megnis, I Vaivade, R Pečulis, Rits J, Prave S, J Kloviņš , Thromb Res. 134(3):659-63 , 2014
• Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes. I Kalniņa, L Zaharenko, I Vaivade, V Rovīte, L Ņikitina-Zaķe, R Pečulis, D Fridmanis, Geldnere K, Jacobsson JA, Almen MS, V Pīrāgs, Schiöth HB, J Kloviņš , Gene. Sep 25;527(2):462-8. , 2013
• Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children Sällman Almén M, Rask-Andersen M, Jacobsson JA, Ameur A, Kalnina I, Moschonis G, Juhlin S, Bringeland N, Hedberg LA, Ignatovica V, Chrousos GP, Manios Y, Klovins J, Marcus C, Gyllensten U, Fredriksson R, Schiöth HB , Int J Obes (Lond) 2012 Apr 24. [Epub ahead of print] , 2012
• Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population. V Rovīte, Latkovskis G, R Pečulis, K Megnis, Schioth HB, I Vaivade, D Fridmanis, Pirags V, Erglis A, J Kloviņš , Mol Biol Rep. [Epub ahead of print] , 2011
• Expression of human melanocortin 4 receptor in Saccharomyces cerevisiae V Rovīte, R Petrovska, D Fridmanis, J Kloviņš , Central European Journal of Biology 6(2): 167-75 , 2011
• Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system. Ignatovica V, Megnis K, Lapins M, Schiöth HB, Klovins J , FEBS J [Epub ahead of print] , 2011
• Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI. I Kalniņa, I Kāpa, Pirags V, V Rovīte, Schiöth HB, J Kloviņš , BMC Med Genet. 10:63 , 2009

• Vietēja mēroga

• CDKN2A mutations and loss of heterozygosity in primary melanomas D Pjanova, Eņģele L, V Rovīte, O Heisele , Proc. Latvian Acad. Sci. Secion B. 60 (2/3):98:100. , 2006

• Patenti

• SET OF OLIGONUCLEOTIDES AND METHOD FOR DETECTION OF FETAL DNA FRACTION IN MATERNAL PLASMA I Radoviča-Spalviņa, V Rovīte, R Pečulis, L Ņikitina-Zaķe, D Fridmanis, J Kloviņš , Europena Patent Office, Application number EP15182851.4 , 2015
• 1,4-Dihidropiridīn-4-IL-piridīnija atvasinājumi kā jauni adenozīna A2A receptora agoallostērisku modulatori Duburs G, Brūvere I., J Kloviņš, R Petrovska, I Mandrika, V Rovīte, Bisenieks E, Uldriķis J, Poikāns J, Vīgante B , LR patents LV 14884 , 2013
• 1,4-Dihidopiridīn-4-il-piridīniju atvasinājumi kā jauni A2A receptora agolallostēriskie modulatori Duburs G, J Kloviņš, Brūvere I., R Petrovska, I Mandrika, V Rovīte, Bisenieks E, Uldriķis J, Poikāns J, Dambrova M, Vilšķērsts R, Vīgante B , LR Patenta pieteikums P-09-19 , 2009

• Konferenču tēzes

• Ģenētisko variantu saistība ar vēnu trombozi Latvijas populācijā V Rovīte, U. Mauriņš, K Megnis, L Ņikitina-Zaķe, J. Rīts, S. Prāve, I Vaivade, J Kloviņš , LU 72. Zinātniskā konference, Rīga, Latvija , 2014
• The susceptibility variants of type two diabetes in extremely obese individuals V Rovīte, R Petrovska, I Vaivade, I Kalniņa, D Fridmanis, L Zaharenko, R Pečulis, V Pīrāgs, Helgi B. Schioth, J Kloviņš , 29th Congress of the Federation of the International Danube Symposia on Diabetes mellitus and 9th Congress of Central European Diabetes, Jūrmala, Latvija , 2014
• Association of polymorphisms representing obesity-related loci comprising FTO and TMEM18 with type 2 diabetes and age at diagnosis of the disease in the population of Latvia. I Kalniņa, L Zaharenko, I Vaivade, V Rovīte, Jacobsson JA, Almen MS, Schiöth HB, V Pīrāgs, J Kloviņš , European Human Genetics Conference. Nürnberg, Germany. P09-136. , 2012
• Analysis of the MC4R in relation to obesity in population of Latvia. V Rovīte, R Petrovska, I Kalniņa, I Vaivade, D Fridmanis, L Zaharenko, R Pečulis, Schioth HB, J Kloviņš , European Human Genetics Conference. Nürnberg, Germany. P09-098. , 2012
• Melanocortin 4 receptor genetics in defining the morbid obesity in general population: common polymorphisms versus mutations. J Kloviņš, V Rovīte, Schioth H, V Pīrāgs , 15th International and 14th European Congress of Endocrinology. Florence, Italy. P1193. , 2012
• P2Y1R gēna polimorfismu raksturojums saistībā ar miokarda infarktu Latvijas populācijā V Rovīte, Latkovskis G., R Pečulis, Megnis K., V Pīrāgs, Ērglis A, J Kloviņš , LU 69. Zinātniskā konference. 2011. Rīga , 2011
• Characterisaion of funcionally important amino acid residues in the human purinergic 12 receptor using yeast Saccharomyces cerevisiae expression system V Rovīte, Megnis K., Lapins M., Schioth H.B., J Kloviņš , 4th Joint German-Italian Purine Club Meeting. 2011. Bonn, GermanyPS 2.10. , 2011

Ātrās saites

• BMC e-pasts
• Iepirkumi
• Iepirkumu arhīvs
• Masu medijiem
• EURAXESS